Somervaille, Tim C.P.: search on Z-Library

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1

Intraocular relapse of childhood acute lymphoblastic leukaemia

Tim C. P. Somervaille, Ian M. Hann, Georgina Harrison, Tim O.B. Eden, Brenda E. Gibson, Frank G. Hill, Chris Mitchell, Sally E. Kinsey, Ajay J. Vora, John S. Lilleyman, on behalf of the MRC childhood

Journal:

British Journal of Haematology

Year:

2003

Language:

english

File:

PDF, 77 KB

english, 2003

2

Leukemogenic Activity of Cohesin Rings True

Williams, Mark S., Somervaille, Tim C.P.

Journal:

Year:

2015

Language:

english

File:

PDF, 455 KB

english, 2015

3

Glycogen synthase kinase 3 in MLL leukaemia maintenance and targeted therapy

Wang, Zhong, Smith, Kevin S., Murphy, Mark, Piloto, Obdulio, Somervaille, Tim C. P., Cleary, Michael L.

Journal:

Year:

2008

Language:

english

File:

PDF, 533 KB

english, 2008

4

CD86 expression as a surrogate cellular biomarker for pharmacological inhibition of the histone demethylase lysine-specific demethylase 1

Lynch, James T., Cockerill, Mark J., Hitchin, James R., Wiseman, Daniel H., Somervaille, Tim C.P.

Journal:

Analytical Biochemistry

Year:

2013

Language:

english

File:

PDF, 760 KB

english, 2013

5

Design of a Biased Potent Small Molecule Inhibitor of the Bromodomain and PHD Finger-Containing (BRPF) Proteins Suitable for Cellular and in Vivo Studies

Igoe, Niall, Bayle, Elliott D., Fedorov, Oleg, Tallant, Cynthia, Savitsky, Pavel, Rogers, Catherine, Owen, Dafydd R., Deb, Gauri, Somervaille, Tim C. P., Andrews, David M., Jones, Neil, Cheasty, Anne,

Journal:

Journal of Medicinal Chemistry

Year:

2017

Language:

english

File:

PDF, 3.45 MB

english, 2017

6

AXL Inhibition Extinguishes Primitive JAK2 Mutated Myeloproliferative Neoplasm Progenitor Cells

Pearson, Stella, Blance, Rognvald, Somervaille, Tim C.P., Whetton, Anthony D., Pierce, Andrew

Journal:

Year:

2019

File:

PDF, 3.19 MB

2019

7

The Histone Demethylase KDM1A Sustains the Oncogenic Potential of MLL-AF9 Leukemia Stem Cells

William J. Harris, Xu Huang, James T. Lynch, James R. Hitchin, Yaoyong Li, Filippo Ciceri, Julian G. Blaser, Brigit F. Greystoke, Allan M. Jordan, Donald J. Ogilvie, Tim C.P. Somervaille

Journal:

Year:

2012

Language:

english

File:

PDF, 37 KB

english, 2012

8

Antagonizing Self-Renewal in Acute Myeloid Leukemia: ID2 Takes the Stage

Deb, Gauri, Somervaille, Tim C.P.

Journal:

Year:

2016

Language:

english

File:

PDF, 421 KB

english, 2016

9

Development of (4-Cyanophenyl)glycine Derivatives as Reversible Inhibitors of Lysine Specific Demethylase 1

Mould, Daniel P., Alli, Cristina, Bremberg, Ulf, Cartic, Sharon, Jordan, Allan M., Geitmann, Matthis, Maiques-Diaz, Alba, McGonagle, Alison E, Somervaille, Tim C. P., Spencer, Gary J., Turlais, Fabric

Journal:

Journal of Medicinal Chemistry

Year:

2017

Language:

english

File:

PDF, 3.26 MB

english, 2017

10

EVI1 oncoprotein expression and CtBP1-association oscillate through the cell cycle

Paredes, Roberto, Schneider, Marion, Pearson, Stella, Teng, Hsiang Yin, Kelly, James R., Pierce, Andrew, Somervaille, Tim C. P., Whetton, Anthony D., Meyer, Stefan

Journal:

Molecular Biology Reports

Year:

2020

File:

PDF, 4.96 MB

2020

11

Development of 5-Hydroxypyrazole Derivatives as Reversible Inhibitors of Lysine Specific Demethylase 1

Mould, Daniel P., Bremberg, Ulf, Jordan, Allan M., Geitmann, Matthis, Maiques-Diaz, Alba, McGonagle, Alison E., Small, Helen F., Somervaille, Tim C.P., Ogilvie, Donald

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2017

Language:

english

File:

PDF, 1.79 MB

english, 2017

12

Disorders of Hemoglobin: Genetics, Pathophysiology, and Clinical ManagementDisorders of Hemoglobin: Genetics, Pathophysiology, and Clinical ManagementSteinbergM H, ForgetB G, HiggsD R, NagelR L1282 pp Price £180; US$275 ISBN 0-521-63266-8 (h/b) Cambridge: Cambridge University Press, 2001

Somervaille, Tim

Journal:

Journal of the Royal Society of Medicine

Year:

2001

Language:

english

File:

PDF, 54 KB

english, 2001

13

Emerging Epigenetic Therapeutic Targets in Acute Myeloid Leukemia

Wingelhofer, Bettina, Somervaille, Tim C. P.

Journal:

Frontiers in Oncology

Year:

2019

Language:

english

File:

PDF, 739 KB

english, 2019

14

Hematopoietic Stem Cell Quiescence Is Maintained by Compound Contributions of the Retinoblastoma Gene Family

Patrick Viatour, Tim C. Somervaille, Shivkumar Venkatasubrahmanyam, Scott Kogan, Margaret E. McLaughlin, Irving L. Weissman, Atul J. Butte, Emmanuelle Passegué, Julien Sage

Journal:

Year:

2008

Language:

english

File:

PDF, 2.20 MB

english, 2008

15

Fatal invasive aspergillosis of the larynx

Williams, Mark S., Ali, Nisha, Nonaka, Daisuke, Bloor, Adrian J., Somervaille, Tim C. P.

Journal:

European Journal of Haematology

Year:

2013

Language:

english

File:

PDF, 141 KB

english, 2013

16

The Menin Tumor Suppressor Protein Is an Essential Oncogenic Cofactor for MLL-Associated Leukemogenesis

Akihiko Yokoyama, Tim C.P. Somervaille, Kevin S. Smith, Orit Rozenblatt-Rosen, Matthew Meyerson, Michael L. Cleary

Journal:

Year:

2005

Language:

english

File:

PDF, 634 KB

english, 2005

17

LSD1 inhibition: a therapeutic strategy in cancer?

Lynch, James T, Harris, William J, Somervaille, Tim C P

Journal:

Expert Opinion on Therapeutic Targets

Year:

2012

Language:

english

File:

PDF, 600 KB

english, 2012

18

Development and evaluation of 4-(pyrrolidin-3-yl)benzonitrile derivatives as inhibitors of lysine specific demethylase 1

Mould, Daniel P., Bremberg, Ulf, Jordan, Allan M., Geitmann, Matthis, McGonagle, Alison E., Somervaille, Tim C.P., Spencer, Gary J., Ogilvie, Donald J.

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2017

Language:

english

File:

PDF, 1.16 MB

english, 2017

19

Identification and characterization of leukemia stem cells in murine MLL-AF9 acute myeloid leukemia

Tim C.P. Somervaille, Michael L. Cleary

Journal:

Year:

2006

Language:

english

File:

PDF, 609 KB

english, 2006

20

LSD1: biologic roles and therapeutic targeting

Maiques-Diaz, Alba, Somervaille, Tim CP

Journal:

Year:

2016

Language:

english

File:

PDF, 1.61 MB

english, 2016

21

Very high frequencies of leukaemia-initiating cells in precursor T-acute lymphoblastic leukaemia may be obscured by cryopreservation

Greystoke, Brigit F., Huang, Xu, Wilks, Deepti P., Atkinson, Shayne, Somervaille, Tim C. P.

Journal:

British Journal of Haematology

Year:

2013

Language:

english

File:

PDF, 155 KB

english, 2013

22

Elevated plasma 2-hydroxyglutarate in acute myeloid leukaemia: association with the IDH1 SNP rs11554137 and severe renal impairment

Wiseman, Daniel H., Small, Helen F., Wilks, Deepti P., Waddell, Ian D., Dennis, Michael W., Ogilvie, Donald J., Somervaille, Tim C. P.

Journal:

British Journal of Haematology

Year:

2014

Language:

english

File:

PDF, 334 KB

english, 2014

23

Hierarchical Maintenance of MLL Myeloid Leukemia Stem Cells Employs a Transcriptional Program Shared with Embryonic Rather Than Adult Stem Cells

Tim C.P. Somervaille, Christina J. Matheny, Gary J. Spencer, Masayuki Iwasaki, John L. Rinn, Daniela M. Witten, Howard Y. Chang, Sheila A. Shurtleff, James R. Downing, Michael L. Cleary

Journal:

Year:

2009

Language:

english

File:

PDF, 1.89 MB

english, 2009

24

Pre-clinical activity of combined LSD1 and mTORC1 inhibition in MLL-translocated acute myeloid leukaemia

Deb, Gauri, Wingelhofer, Bettina, Amaral, Fabio M. R., Maiques-Diaz, Alba, Chadwick, John A., Spencer, Gary J., Williams, Emma L., Leong, Hui-Sun, Maes, Tamara, Somervaille, Tim C. P.

Journal:

Year:

2019

File:

PDF, 2.50 MB

2019

25

Targeted nanopore sequencing for the identification of ABCB1 promoter translocations in cancer

Williams, Mark S., Basma, Naseer J., Amaral, Fabio M. R., Williams, Gillian, Weightman, John P., Breitwieser, Wolfgang, Nelson, Louisa, Taylor, Stephen S., Wiseman, Daniel H., Somervaille, Tim C. P.

Journal:

Year:

2020

File:

PDF, 2.11 MB

2020

26

ORY-1001, a Potent and Selective Covalent KDM1A Inhibitor, for the Treatment of Acute Leukemia

Maes, Tamara, Mascaró, Cristina, Tirapu, Iñigo, Estiarte, Angels, Ciceri, Filippo, Lunardi, Serena, Guibourt, Nathalie, Perdones, Alvaro, Lufino, Michele M.P., Somervaille, Tim C.P., Wiseman, Dan H.,

Journal:

Year:

2018

Language:

english

File:

PDF, 6.43 MB

english, 2018

27

Grist for the MLL: how do MLL oncogenic fusion proteins generate leukemia stem cells?

Tim C. P. Somervaille, Michael L. Cleary

Journal:

International Journal of Hematology

Year:

2010

Language:

english

File:

PDF, 305 KB

english, 2010

28

Frequent Derepression of the Mesenchymal Transcription Factor Gene FOXC1 in Acute Myeloid Leukemia

Somerville, Tim D.D., Wiseman, Daniel H., Spencer, Gary J., Huang, Xu, Lynch, James T., Leong, Hui Sun, Williams, Emma L., Cheesman, Edmund, Somervaille, Tim C.P.

Journal:

Year:

2015

Language:

english

File:

PDF, 3.02 MB

english, 2015

29

The Diverse Consequences of FOXC1 Deregulation in Cancer

Gilding, L. Niall, Somervaille, Tim C. P.

Journal:

Year:

2019

Language:

english

File:

PDF, 785 KB

english, 2019

30

Different levels of p38 MAP kinase activity mediate distinct biological effects in primary human erythroid progenitors

Tim C. P. Somervaille, David C. Linch, Asim Khwaja

Journal:

British Journal of Haematology

Year:

2003

Language:

english

File:

PDF, 413 KB

english, 2003

31

Mutant CEBPA: Priming Stem Cells for Myeloid Leukemogenesis

Tim C.P. Somervaille, Michael L. Cleary

Journal:

Year:

2009

Language:

english

File:

PDF, 136 KB

english, 2009

32

PU.1 and Junb: Suppressing the formation of acute myeloid leukemia stem cells

Tim C.P. Somervaille, Michael L. Cleary

Journal:

Year:

2006

Language:

english

File:

PDF, 142 KB

english, 2006

33

Sudden onset bilateral deafness as a presentation of chronic myeloid leukaemia

Alimam, Samah M., Mamat, Mohd K., Kulkarni, Samar, Somervaille, Tim C. P.

Journal:

British Journal of Haematology

Year:

2013

Language:

english

File:

PDF, 75 KB

english, 2013

34

Revert the SIRT: Normalizing SIRT1 Activity in Myelodysplastic Stem Cells

Simeoni, Fabrizio, Somervaille, Tim C.P.

Journal:

Year:

2018

Language:

english

File:

PDF, 487 KB

english, 2018

35

Chronic myelomonocytic leukaemia stem cell transcriptomes anticipate disease morphology and outcome

Wiseman, Daniel H, Baker, Syed M, Dongre, Arundhati V, Gurashi, Kristian, Storer, Joanna A, Somervaille, Tim CP, Batta, Kiran

Journal:

Year:

2020

File:

PDF, 4.44 MB

2020

36

KDM1 histone lysine demethylases as targets for treatments of oncological and neurodegenerative disease

Maes, Tamara, Mascaró, Cristina, Ortega, Alberto, Lunardi, Serena, Ciceri, Filippo, Somervaille, Tim C P, Buesa, Carlos

Journal:

Year:

2015

Language:

english

File:

PDF, 2.19 MB

english, 2015

37

Tissue-inappropriate derepression of FOXC1 is frequent and functional in human acute myeloid leukemia

Somerville, Tim D. D., Somervaille, Tim C. P.

Journal:

Molecular & Cellular Oncology

Year:

2016

Language:

english

File:

PDF, 1.65 MB

english, 2016

38

Derepression of the Iroquois Homeodomain Transcription Factor Gene IRX3 Confers Differentiation Block in Acute Leukemia

Somerville, Tim D.D., Simeoni, Fabrizio, Chadwick, John A., Williams, Emma L., Spencer, Gary J., Boros, Katalin, Wirth, Christopher, Tholouli, Eleni, Byers, Richard J., Somervaille, Tim C.P.

Journal:

Year:

2018

Language:

english

File:

PDF, 3.59 MB

english, 2018

39

LSD1 inhibitors disrupt the GFI1 transcription repressor complex

Maiques-Diaz, Alba, Lynch, James T., Spencer, Gary J., Somervaille, Tim C.P.

Journal:

Molecular & Cellular Oncology

Year:

2018

Language:

english

File:

PDF, 1.99 MB

english, 2018

40

Response to tyrosine kinase inhibitors in myeloid neoplasms associated with PCM1 â JAK2 , BCRâJAK2 and ETV6âABL1 fusion genes

Schwaab, Juliana, Naumann, Nicole, Luebke, Johannes, Jawhar, Mohamad, Somervaille, Tim C.P., Williams, Mark S., Frewin, Rebecca, Jost, Philipp J., Lichtenegger, Felix S., La RosÃ©e, Paul, Storch, Nico

Journal:

American Journal of Hematology

Year:

2020

File:

PDF, 1.82 MB

2020

41

Variable product purity and functional capacity after CD34 selection: a direct comparison of the CliniMACS® (v2·1) and Isolex® 300i (v2·5) clinical scale devices

Michael J. Watts, Tim C. P. Somervaille, Stuart J. Ings, Forhad Ahmed, Asim Khwaja, Kwee Yong, David C. Linch

Journal:

British Journal of Haematology

Year:

2002

Language:

english

File:

PDF, 121 KB

english, 2002

42

Dynamic induction of drug resistance through a stress-responsive enhancer in acute myeloid leukemia

Williams, Mark S., Somervaille, Tim C. P.

Journal:

Molecular & Cellular Oncology

Year:

2020

File:

PDF, 1.10 MB

2020

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